When an infected bolt of cloth carries plague from London to an isolated mountain village, a housemaid named Anna Frith emerges as an unlikely heroine and healer. Through Anna's eyes we follow the story of the plague year, 1666, as her fellow villagers make an extraordinary choice: convinced by a visionary young minister, they elect to quarantine themselves within the village boundaries to arrest the spread of the disease. But as death reaches into every household, faith frays. When the villagers turn from prayers to murderous witch-hunting, Anna must confront the deaths of family members, the disintegration of her community, and the lure of illicit love. As she struggles to survive. a year of plague becomes instead an annus mirabilis, a "year of wonders".